S-23

S-23

S-23 is perhaps the most powerful SARM on the market
today. It is becoming extremely popular, but it can be very
dangerous if used improperly.
It was developed by GTx, Inc. but unlike other SARMs by
this company, it was not developed to treat muscle wasting
conditions or osteoporosis. Instead, it was developed as a
potential form of oral contraception for males.
It never reached clinical trials, so we have no scientific data
about the impact of S-23 on humans. It is worth noting,
however, that the short half-life information we have comes
from preclinical studies. We do not know for sure what the
half-life is in humans.

BENEFITS

MUSCLE
It is hard to quantify how much muscle S-23 can help you
gain because it is rarely used as a bulking compound.
People who use it on a caloric deficit report a noticeable
increase in muscle mass.
Furthermore, this compound is almost always stacked with
Testosterone and other anabolics, making it hard to guess
what kind of results one would get from S-23 alone.
By reviewing anecdotal data, we can conclude that it will
probably accrue a similar amount of muscle mass to
Ligandrol and Testolone.

STRENGTH AND PERFORMANCE
According to anecdotal information, S-23 is extremely
effective at increasing strength. People report massive
increases in strength and performance even when dropping
calories and losing weight.
This makes S-23 an excellent choice when eating on a very
aggressive caloric deficit and/or when preparing for a
bodybuilding contest.

FAT LOSS
Pre-clinical animal studies on S-23 claim that this
compound can burn fat on a dose-dependent manner.
We cannot extrapolate this information and confirm that this
phenomenon applies to humans as well, but a large number
of users claim that S-23 increases metabolism so much,
that it can boost fat loss. Take that information with a grain
of salt.

BONES AND JOINTS
S-23, like all SARMs, will increase the density of your bones
and it will make them stronger.
It does not appear to have any impact on joints nor tendons.

RECOVERY
S-23 will make your recovery faster. You will feel less sore
the next day and your muscles will be ready to work out
again a lot sooner.

COSMETIC BENEFITS
The cosmetic benefits of S-23 are the main reason why so
many people choose to take it despite the risks that come
with it.

SIDE EFFECTS

TESTICULAR SHUTDOWN
All SARMs can potentially cause testicular shutdown if
taken in extreme amounts during large periods of time, but
S-23 will cause complete shutdown even at small dosages
taken for short periods of time. This is normal, given that it
was developed as an oral contraceptive and dropping LH
and FSH levels to 0 is necessary in order to achieve that.
Keep in mind that in most cases S-23 on its own will not
cause infertility.
Since S-23 will crash your Testosterone down to a
negligible level, there will be no conversion of Testosterone
into Estrogen and you will feel like complete garbage
throughout the cycle UNLESS you are running a
Testosterone base of some sort. This also makes a PCT
mandatory (More on that in the chapter about On-Cycle
Therapy and Post-Cycle Therapy).
The consequences of testosterone suppression or
shutdown are:
– Decreased libido
– Weaker erections
– Lethargy
– Lack of motivation
– Irritability
– Testicular atrophy
– Testicular pain

If you do not have a Testosterone base, you will suffer from
every single one of these side-effects, and your life will
become miserable until you do a PCT.
It is worth noting that S-23, like all SARMs, will decrease
your SHBG. This will lead to an increase in your free
testosterone levels which usually causes libido, motivation
and well-being to improve during the cycle, but ONLY if you
have a testosterone base.
Anecdotal bloodwork provided by users confirms the
effectiveness of S-23 at crashing LH and FSH levels,
therefore we can conclude that it is an effective oral
contraceptive for men (you should still use condoms).

CHOLESTEROL
S-23, like all SARMs, will mess with your HDL and LDL
cholesterol levels.
Your HDL (good) cholesterol will be significantly decreased,
and your LDL (bad) cholesterol will probably increase.
The impact of S-23 on the lipid panel will be harder than
that of most other SARMs, and it will be comparable to that
of actual oral steroids.
This side-effect will not manifest itself by impacting the way
you feel, so you will have no symptoms. Getting bloodwork
at the end of a cycle will show the true impact of the SARM
on your lipid panel.